In Zurich there are SIB Groups based at both the University of Zurich and ETH Zurich

The University of Zurich hosts one group in the Department of Biochemistry and the second in the Institute of Molecular Biology.

The Swiss Federal Institute of Technology Zurich (ETHZ) hosts two groups in the Department of Computer Science and one, loated in Basel, in the Department of Biosystems Science and Engineering affiliated with the Department of Computer Science.